2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-130346
    DBCO-PEG4-DBCO 2182601-68-7
    DBCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG4-DBCO
  • HY-141238
    HO-PEG24-OH 2243942-52-9 ≥98.0%
    HO-PEG24-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    HO-PEG24-OH
  • HY-44141
    tert-Butyl 3-(2-iodoethoxy)propanoate 2296723-16-3
    tert-Butyl 3-(2-iodoethoxy)propanoate is a PROTAC linker, which refers to the PEG composition. tert-Butyl 3-(2-iodoethoxy)propanoate can be used in the synthesis of PROTAC FAK degrader 1 (HY-119932).
    tert-Butyl 3-(2-iodoethoxy)propanoate
  • HY-W190796A
    Mal-PEG3-NH2 TFA 2830214-77-0 99.07%
    Mal-PEG3-NH2 TFA is a linear heterobifunctional PEG crosslinker with Maleimide (HY-W007324) and amine. Mal-PEG3-NH2 TFA is a non-degradable (non-cleavable) PROTAC linker.
    Mal-PEG3-NH2 TFA
  • HY-135796
    m-PEG3-OH 112-35-6 99.78%
    m-PEG3-alcohol is a?PEG-based PROTAC linker?can be used in the synthesis of PROTACs.
    m-PEG3-OH
  • HY-140209
    Amino-PEG7-amine 332941-25-0
    Amino-PEG7-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG7-amine
  • HY-138524
    Thiol-PEG2-acid 1379649-73-6
    Thiol-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Thiol-PEG2-acid
  • HY-141370
    Bromo-PEG1-CH2-Boc 157759-50-7 ≥98.0%
    Bromo-PEG1-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG1-CH2-Boc
  • HY-141213
    Bromo-PEG2-alcohol 57641-66-4 98.98%
    Bromo-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG2-alcohol
  • HY-140977
    Mal-amido-PEG12-NHS ester 2101722-60-3
    Mal-amido-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG12-NHS ester
  • HY-108370
    N33-TEG-COOH 201467-81-4 ≥98.0%
    N33-TEG-COOH (N3-TEG-COOH) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. N33-TEG-COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N33-TEG-COOH
  • HY-W018154
    H-Glu-OtBu 45120-30-7 ≥98.0%
    H-Glu-OtBu is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-Glu-OtBu is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2
    H-Glu-OtBu
  • HY-130169
    Azido-PEG9-amine 1207714-69-9 98.52%
    Azido-PEG9-amine is a non-cleavable 9 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG9-amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG9-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG9-amine
  • HY-133174
    Biotin-PEG5-azide 1163732-89-5
    Biotin-PEG5-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTAC. Biotin-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Biotin-PEG5-azide
  • HY-140691
    m-PEG-mal (MW 10000) 99.89%
    m-PEG-mal (MW 10000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG-mal (MW 10000)
  • HY-140614
    DNP-PEG4-NHS ester 858126-78-0
    DNP-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    DNP-PEG4-NHS ester
  • HY-W017440
    Triethylene glycol 112-27-6 99.88%
    Triethylene glycol (PROTAC Linker 25) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Triethylene glycol
  • HY-W040133
    Mal-amido-PEG8-NHS ester 756525-93-6 99.23%
    Mal-amido-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG8-NHS ester
  • HY-W040257
    NH2-PEG6-CH2CH2COOH 905954-28-1
    NH2-PEG6-CH2CH2COOH is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). NH2-PEG6-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH2-PEG6-CH2CH2COOH
  • HY-W051634
    Propargyl-PEG2-amine 944561-44-8 99.64%
    Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG2-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG2-amine
PROTAC Linkers Isoform Comparison

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